Ex Vivo Human Placental Transfer of Rifampin and Rifabutin
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چکیده
منابع مشابه
Ex Vivo Human Placental Transfer of Rifampin and Rifabutin
OBJECTIVE The purpose of this study was to determine the ex vivo human placental transfer of rifampin and rifabutin. METHODS Seven placentas from uncomplicated term vaginal or cesarean deliveries were studied utilizing the ex vivo single cotyledon perfusion system. Antipyrine was used for the reference compound in the determination of the clearance indices of rifampin and rifabutin. RESULTS...
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OBJECTIVE The purpose of this study was to determine the ex vivo human placental transfer of trovafloxacin from the maternal circulation to the fetal circulation. METHODS Six placentas from uncomplicated, term, vaginal or cesarean deliveries were studied using the ex vivo isolated cotyledon perfusion chamber; 14C-antipyrine was used as a reference compound to determine the clearance index (CI...
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OBJECTIVE The transfer of anti-human immunodeficiency virus (HIV) drugs has been studied in the ex vivo human placental model. There is a paucity of information on the placental transfer of these drugs because of ethical considerations and the expense involved in the use of the non-human primate model. METHODS The standardized ex vivo human placental model was used in these studies and the cl...
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Placental transfers of the HIV nonnucleoside reverse transcriptase inhibitor rilpivirine were investigated in 8 term human cotyledons perfused with rilpivirine (400 ng/ml) in the maternal-to-fetal direction. The mean fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 15 to 90 min) was 26% ± 8% (mean ± standard deviation), and the clearance index (rilpivirine FTR/antipy...
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ژورنال
عنوان ژورنال: Infectious Diseases in Obstetrics and Gynecology
سال: 1996
ISSN: 1064-7449,1098-0997
DOI: 10.1155/s1064744996000646